This monograph examines the role of manipulation in theories of causation, with a particular focus on modern theories that aim to explain the meaning of causal claims in terms of what happens under an intervention. Beyond the philosophical theories that are reviewed and assessed, the investigation also connects both to new powerful scientific methods of stating and testing causal models, and questions about how our individual familiarity with the phenomenon of causation is formed when we interact with our environment through manipulations. This is a Doctoral Thesis in Theoretical Philosophy at Stockholm University, Sweden 2020